Breaking the Cycle of Relapse: Unraveling the Psychological and Neurobiological Impact of Boredom in Youth Addiction Recovery
- Dr. Wesley Sassaman, DNP, MSN-NE, MPH, MBA, FNP-C, CARN-AP
- Feb 15
- 17 min read
by Dr. Wesley Sassaman, DNP, MSN-NE, MPH, MBA, FNP-C, CARN-AP
Introduction
Boredom. It’s a feeling we’ve all experienced, yet for teens and young adults recovering from substance use, it can become a dangerous tipping point. The link between boredom and drug relapse in this vulnerable population is a multifaceted issue involving both psychological and neurobiological mechanisms. Boredom, an aversive emotional state, can lead to impulsive behaviors and emotional dysregulation—key contributors to relapse. On a neurobiological level, boredom affects brain circuits related to reward and stress, which play a critical role in addiction and relapse.
This document dives deep into these intricate mechanisms, shedding light on why boredom isn’t just a harmless state but a critical factor in recovery. By unpacking the science behind these issues, it reveals how impulsivity, emotional regulation, and changes in the brain's reward systems heighten the risk of relapse.
Understanding these mechanisms is more than an academic exercise. It’s a necessity for creating meaningful prevention and intervention strategies that safeguard young lives. For parents, caregivers, and professionals, this exploration offers essential insights into the triggers, patterns, and underlying processes that can lead to relapse—and how to counteract them. Through this lens, we gain tools to foster resilience, interrupt harmful cycles, and guide young people toward lasting recovery.
Psychological Mechanisms
Impulsivity and Emotional Dysregulation: Boredom has been shown to increase impulsive decision-making, which is a risk factor for relapse. A study demonstrated that induced boredom heightened impulsive choices in both cocaine users and controls, indicating a general effect of boredom on impulsivity (Chao et al., 2023). Additionally, boredom is linked to emotional dysregulation, where individuals may use substances as a coping mechanism to manage negative emotions (Cicolini et al., 2023).
Coping Strategies: Maladaptive coping strategies, such as avoidance, are associated with higher levels of emotional dysregulation, with boredom acting as a mediator in this relationship. This suggests that boredom can exacerbate the use of ineffective coping strategies, increasing the risk of relapse (Cicolini et al., 2023).
Take Home for Parents. Recovering from addiction is a challenging process, not just for teens or young adults but also for their families. A key factor parents must understand is the strong connection between boredom and relapse. Boredom isn’t just a harmless absence of activity—it’s an emotional void that can lead to impulsive decisions and regression. Many of the patients I’ve worked with over the years as a frontline addiction specialist have told me that boredom was the main reason for their relapse. To address this transient but powerful emotional state with absolute certainty, it takes a partnership between parents and behavioral health counselors. Both roles are essential in helping your child manage feelings of boredom and stay on the path to lasting recovery.
Behavioral health counselors play a vital role in supporting teens and young adults through these vulnerable moments. It is essential that patients work with a behavioral health counselor on a routine basis to ensure consistent care and guidance as they navigate challenges. Using tools like cognitive behavioral therapy (CBT), mindfulness training, and healthy coping techniques, counselors guide your child in identifying and addressing the triggers that lead to boredom. They work one-on-one to help build self-awareness, restructure negative thought patterns, and develop problem-solving skills. For example, through CBT, your child can learn to reframe perceptions of boredom and approach it as a manageable challenge rather than a trigger for unhealthy behavior. Counselors also introduce mindfulness practices like meditation and guided breathing, which teach emotional regulation and help your teen pause before reacting impulsively to boredom.
Parents, however, play an equally important role. Together with the counselor, you must ensure your child has the external support and environment necessary to put these techniques into practice. A “50-50” partnership between family and counseling professionals is crucial. While counselors provide professional expertise, parents contribute continuous structure, encouragement, and daily involvement in the recovery process. This shared responsibility ensures that every moment of vulnerability—including boredom—is met with proactive measures.
For your part, start by working closely with your child’s counselor. Understand the triggers and patterns that leave your child susceptible to boredom. Counselors may identify gaps in your child’s schedule, lack of social connections, or unresolved emotional stressors. Using their insights, you can create a home routine with your child that incorporates structure and fulfilling activities. Encourage hobbies and pursuits—whether it’s art, volunteering, fitness, or other personal passions—that align with their strengths and interests. By filling unstructured time in meaningful ways, you reduce the risk of idle hours that could lead to boredom and relapse.
At the same time, reinforce the coping strategies your child learns during therapy. For instance, have open conversations about how they can safely manage boredom when it arises. Help them practice breathing exercises, journaling, or other mindfulness activities introduced by their counselor. Together, you can build a “toolkit” of options, so your teen has reliable outlets to turn to at any moment. This collaboration ensures that the tools counselors provide are sustained and supported within the family dynamic.
Another essential part of this partnership is helping your child strengthen their support network. Behavioral health counselors often recommend peer recovery groups or group therapy sessions, which provide a social connection and accountability that can ease feelings of isolation. Work alongside them to facilitate these connections. At home, foster a sense of community by spending regular quality time together, whether through meals, outings, or simple family game nights. By blending professional guidance with ongoing support from loved ones, your child has the safety net they need to tackle challenges head-on.
Neurobiological Mechanisms
Brain Circuitry and Neurotransmitter Systems: Chronic drug exposure alters brain circuits, particularly the mesocorticolimbic dopaminergic system, which is involved in reward processing. These changes increase sensitivity to stress and drug-related cues, making individuals more prone to relapse (Stewart, 2008). The corticotropin-releasing factor (CRF) and noradrenergic systems also play roles in stress responses, which are heightened during boredom (Weiss et al., 2006). Corticotropin-Releasing Factor (CRF) and the noradrenergic system play key roles in how the body and brain respond to stress and boredom. CRF, released by the hypothalamus, triggers a stress response by activating the pituitary gland and adrenal glands, leading to cortisol release. This hormonal cascade readies the body to manage stress while also influencing behavior, such as increasing alertness and anxiety.
The noradrenergic system, through the neurotransmitter norepinephrine, governs the fight-or-flight response. During stress, norepinephrine levels rise, heightening alertness, heart rate, and energy to prepare for immediate action. Although boredom is less intense than stress, it can still activate these systems mildly. This response drives restlessness and a need for stimulation, as the brain seeks engagement to alleviate dissatisfaction.
For parents, understanding these mechanisms can clarify why children become restless or anxious when bored. Providing activities that captivate their interests can reduce mild stress responses linked to boredom. Balancing stimulating activities with relaxation can help support children’s emotional and physiological well-being by minimizing unnecessary stress and fostering a healthier environment.
Take Home for Parents. The mesocorticolimbic dopaminergic system plays a crucial role in the brain's reward system, influencing behaviors related to motivation, reward-seeking, and learning. This system is significantly impacted by the balance between boredom and relapse, as it mediates the reinforcement of rewarding behaviors and the avoidance of negative outcomes. The interplay between dopamine signaling and reward processing is complex, involving various neural circuits and mechanisms that can lead to both adaptive and maladaptive behaviors.
Dopaminergic System and Reward Processing
The mesocorticolimbic pathway, primarily involving the ventral tegmental area (VTA) and the nucleus accumbens (NAc), is central to reward processing. Dopamine release in this pathway is associated with reward prediction errors (RPEs), which are crucial for reinforcement learning and decision-making (Schultz, 2024) (Jeong et al., 2022).
Take Home for Parents. Reward Prediction Error (RPE) is the brain's way of measuring the gap between what we expect and what happens. A better-than-expected result triggers a positive RPE, reinforcing the behavior that led to it, while a worse outcome causes a negative RPE, prompting adjustment. This process is central to learning and drives us to adapt behaviors based on experiences.
Consider a paleolithic cavewoman exploring unfamiliar terrain. She stumbles upon a spring-fed water source, an unexpected and vital find for her clan's survival. This surprising discovery triggers a strong positive RPE, embedding the importance of exploration into her brain. The dopaminergic system modulates this process by influencing synaptic plasticity in the brain, creating “latent” attractors that represent potential goals (Naudé et al., 2024). These attractors make certain goals—like seeking water—more mentally accessible, encouraging behaviors that maximize rewards and support survival. Over time, the dopaminergic system helps refine choices through reinforcement learning, driving behaviors toward better outcomes (Schultz, 2024).
When it comes to recovery, RPE also plays a critical role. Imagine someone recovering from fentanyl addiction who, while driving, unexpectedly passes their dealer's apartment. This sudden encounter activates dopamine release (cue-elicited response), creating a strong positive RPE linked to past substance use. This surge can intensify cravings, making it more challenging to resist relapse, even when the person was initially committed to staying abstinent. Dopamine’s influence here highlights how the brain prioritizes perceived rewards, which can undermine recovery efforts if not managed carefully.
Parents and caregivers can help mitigate these risks by fostering predictable, stable environments that reduce exposure to unexpected triggers, minimizing unplanned RPE responses. Encouraging consistent reinforcement of healthy habits—whether through celebrating achievements or nurturing new passions—builds alternative reward pathways rooted in positive experiences. By embedding new “goals” into the brain’s dopaminergic system, such as finding joy in a skill or connection in relationships, individuals can access healthier sources of satisfaction.
Mindfulness and coping techniques are also critical; they empower individuals to understand and regulate their responses when unexpected situations arise. By recognizing how dopamine and RPE shape their behavior and cravings, individuals can better manage triggers and stay in control of their recovery.
Understanding RPE and dopamine's role in synaptic plasticity gives parents a deeper insight into the neuroscience behind behavior. With this knowledge, they can offer support that not only addresses the risk of relapse but also fosters the resilience and adaptability needed for lasting recovery and well-being
Impact of Boredom and Relapse
Boredom can lead to a decrease in dopamine activity, which may result in anhedonia, a condition characterized by a diminished ability to experience pleasure. This is often observed in major depressive disorder (MDD) and is linked to dysfunctions in the reward network (Guo et al., 2023) (Baudewin, 2022).
The balance between boredom and relapse is critical in conditions like substance use disorders (SUDs), where dysregulated dopamine signaling can lead to increased reward-seeking behavior despite adverse consequences (Jovanoski et al., 2023) (Shota, 2022).
In the context of stress and depression, altered corticostriatal connectivity can exacerbate dysregulated motivated behaviors, contributing to the cycle of boredom and relapse (Siemsen et al., 2022).
Take Home for Parents. Buprenorphine is an important medication used to treat opioid use disorder (OUD). Often paired with naloxone to help prevent misuse, it plays a key role in reducing cravings and minimizing the risk of relapse. However, recovery from addiction goes beyond reducing substance use—it also involves addressing mental health. Many individuals recovering from opioid addiction experience depression, which can make recovery more difficult. Studies emphasize that treating depression alongside addiction is vital to improve outcomes and support long-term success (Krishnamurthy et al., 2023).
Antidepressants are often used safely with buprenorphine to help manage depressive symptoms, offering hope for a more effective recovery process. For treating depression in individuals using buprenorphine, Selective Serotonin Reuptake Inhibitors (SSRIs), such as fluoxetine and sertraline, are commonly prescribed. These medications are effective, well-tolerated, and show no significant interactions with buprenorphine (Krishnamurthy et al., 2023).
Similarly, Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), including duloxetine, can combat both depression and anxiety, which are often present in those with substance use disorders (Krishnamurthy et al., 2023). Remarkably, research indicates that buprenorphine itself may offer mild antidepressant benefits, likely due to its effects on opioid receptors that influence mood regulation (Riblet et al., 2023; Bastien et al., 2022). This dual action—addressing addiction and potentially aiding depression—makes buprenorphine a unique option in treatment plans.
Along with medication, integrated care is critical for success. Behavioral therapies like cognitive-behavioral therapy (CBT) can address the psychological and emotional challenges associated with addiction and depression (Shadowen et al., 2022). Additionally, regular monitoring and adjustments to treatment plans ensure medications and therapies are working effectively (Bastien et al., 2022). To provide the best chance at recovery, a well-rounded approach that includes both mental health support and addiction treatment is essential. By addressing addiction and mental health together, individuals and their families can achieve sustainable, long-term recovery.
Neural Mechanisms and Behavioral Outcomes
Dopamine’s Role in Survival, Learning, Boredom, and Relapse
Dopamine is a versatile and powerful neurotransmitter that plays a central role in survival, shaping how we learn, adapt, and respond to our environment. Traditionally, dopamine has been understood through its role in Reward Prediction Errors (RPEs)—adjusting behavior when there’s a mismatch between expected and actual outcomes (Schultz, 2024).
However, research reveals dopamine also supports prospective learning, which anticipates future outcomes, and retrospective learning, which infers the causes of past experiences (Jeong et al., 2022). These functions are further complicated by dopamine's influence on states like boredom, which can drive adaptive exploration—or, in adverse contexts, lead to maladaptive behaviors like relapse. By exploring these processes through the relatable lens of a Paleolithic cavewoman’s survival, parents can better understand these mechanisms’ implications for modern behaviors like addiction and relapse.
Reward Prediction Errors (RPEs) and Survival Learning
The traditional role of dopamine has been tied to Reward Prediction Errors (RPEs), where dopamine signals the difference between expected and received outcomes (Schultz, 2024). This signal helps individuals adjust their actions to optimize future benefits or avoid mistakes.
Example of RPE in Survival:Imagine a Paleolithic cavewoman scavenging for roots. She digs into what looks like a fertile patch, expecting to find tubers, but instead discovers it barren. This mismatch between expectation and result triggers a negative prediction error, reducing dopamine activity and discouraging her from digging in similar areas. Conversely, if she stumbles upon a trove of nutritious tubers unexpectedly, it triggers a positive prediction error, causing a surge in dopamine that reinforces her decision to revisit or search similar environments in the future.
This RPE mechanism allows adaptive responses to immediate situations, such as finding food or avoiding unproductive efforts (Schultz, 2024). However, dopamine’s influence stretches beyond immediate reward prediction.
Prospective and Retrospective Learning in Adaptive Behavior
Recent research highlights that dopamine facilitates prospective learning, where individuals use cues to predict future events, and retrospective learning, where they infer the causes of outcomes (Jeong et al., 2022). These processes expand our understanding of dopamine’s role in survival and decision-making beyond simple RPE signaling.
Prospective Learning - Prospective learning leverages dopamine to motivate behavior with forward-looking predictions (Jeong et al., 2022).
Example of Prospective Learning:Imagine our cavewoman sees vultures circling in the sky. Her previous experiences tell her this likely indicates a nearby carcass, which could be a food source. Dopamine sharpens her focus and motivation to investigate, helping her capitalize on this predictive cue to potentially secure a reward (Schultz, 2024). This function emphasizes how dopamine primes individuals to anticipate and act on favorable outcomes.
Retrospective Learning
Retrospective learning involves forming causal associations between past events and their outcomes (Jeong et al., 2022). Here, dopamine reinforces these connections, enabling more comprehensive learning.
Example of Retrospective Learning:Suppose our cavewoman stumbles upon a stream while wandering a rocky valley. Later, as she reflects on this discovery, she remembers hearing birds chirping nearby earlier in the day. Retrospectively, her brain, fueled by dopamine, links the bird sounds to the presence of water. This causal association ensures she searches for similar bird sounds when water is needed, critical for surviving in drought-prone environments (Hamburger, 2022).
Dopamine's ability to piece together connections between seemingly unrelated events ensures long-term adaptability in survival scenarios (Jeong et al., 2022).
The Role of Boredom in Exploration and Relapse
While dopamine encourages survival and adaptive behaviors, it also drives exploration during states of boredom. Boredom signals that current activities or environments no longer yield sufficient stimulation or rewards, pushing individuals to seek novelty (Chou & D'Orsogna, 2022). Though useful for survival, this drive can open pathways to problematic behaviors like relapse when coupled with dopamine-reinforced memories of past rewards.
Boredom and Adaptive Exploration
Example of Boredom-Induced Exploration:Imagine our cavewoman gathering berries from the same bushes every day. Over time, the bushes yield fewer berries, and the diminishing dopamine response makes the activity feel unproductive and tiresome. This sense of boredom motivates her to venture into the unknown, prompting exploratory behavior that can lead her to new berry patches or other resources (Hamburger, 2022). This example demonstrates boredom's positive function in stimulating curiosity and ensuring resource discovery.
Boredom as a Gateway to Relapse
Boredom can, however, serve as a gateway to relapse, leading individuals to repeat behaviors tied to past rewards—even those with harmful consequences (Blanco-Pozo et al., 2024).
Example of Relapse via Causal Associations:Suppose the cavewoman once found abundant food in a cave but was later attacked by a predator there. The initial dopamine rush from discovering food created a powerful association between the cave and reward. The memory of the predator introduced a competing association of danger. After weeks of hunger, her desperation might drive her to return to the cave, despite knowing the risks. This relapse-like behavior reflects dopamine’s reinforcement of past rewards overriding caution (Jeong et al., 2022). The same mechanism underpins modern addiction relapse, where dopamine links environmental cues to drug use, creating triggers difficult to resist.
Implications for Modern Behaviors Like Drug Relapse
These ancient survival mechanisms persist in the modern world, especially in the context of addiction and relapse. Dopamine encodes strong causal associations between rewards (e.g., drugs) and contextual factors like locations, people, or emotions (Jeong et al., 2022). These memories can make certain “triggers” unavoidable.
Boredom in Addiction
Boredom plays an outsized role in relapse. When individuals in recovery lack rewarding or engaging activities, their minds may seek stimulation by falling back on familiar behaviors—like drug use (Chou & D'Orsogna, 2022). Just as the cavewoman returned to a dangerous cave driven by hunger, a recovering individual might relapse into harmful habits to escape the discomfort of boredom.
Relapse and Triggers
Environmental cues, such as the sight of a place associated with drug use or the experience of a specific emotion, can activate dopamine-driven memories and urges, pulling someone toward old patterns, no matter how long they’ve been sober (Jeong et al., 2022; Blanco-Pozo et al., 2024).
Takeaway for Parents. Understanding dopamine’s multifaceted role helps parents grasp why boredom and relapse can be so interconnected. For the Paleolithic cavewoman, dopamine ensured survival by encouraging exploration, learning from past events, and returning to behavior associated with rewards. Yet, in modern contexts, this same system can result in maladaptive behaviors if properly rewarding alternatives aren’t present.
For children or individuals in recovery, boredom isn’t just idle restlessness—it’s a potential driver toward risky behaviors, fueled by dopamine’s push for stimulation. By fostering enriching, engaging environments and positive associations, parents can help mitigate the risk of boredom turning into relapse. Research by Jeong et al. (2022) and others underscores the importance of understanding dopamine’s broader role, while insights from ancient survival contexts shed light on the adaptability—and vulnerability—of this essential brain system.
Cue-Induced Relapse: The paraventricular nucleus of the thalamus (PVT) and its connections with the prelimbic cortex are involved in cue-induced drug-seeking behavior. Boredom may enhance the salience of drug-related cues, increasing the likelihood of relapse (Kuhn et al., 2021). While boredom is a significant factor in relapse, other elements such as stress, environmental cues, and individual differences in neurobiological responses also play crucial roles. For instance, stress and drug-related cues can trigger memories of drug use, leading to cravings and relapse (Mao et al., 2024). Additionally, individual differences in brain activity, such as blunted anterior insula responses during loss anticipation, can predict relapse, highlighting the complexity of relapse mechanisms (MacNiven et al., 2023). Understanding these diverse factors is essential for developing comprehensive prevention and intervention strategies.
Conclusion
I want to take a moment to apologize if we wandered a bit deep into the intricate workings of the brain’s neural circuitry. Understanding dopamine pathways and neurobiological mechanisms can feel like putting together a complex puzzle. But hopefully, this exploration has offered you a clearer picture of how boredom, impulse control, and emotional regulation intertwine to create risks for relapse in teens and young adults.
Now, you know that boredom isn't just about having "nothing to do." For a teen or young adult in recovery, it's a potent emotional state that can light a path back to harmful behaviors. You've learned how impulsivity, emotional dysregulation, and even subtle triggers in the brain's reward systems can push someone toward relapse. And most importantly, you've seen how partnering with behavioral health counselors, fostering structured routines, and providing a loving support system can open a way forward.
Parents, this knowledge arms you with powerful tools to safeguard your child’s future. You’re now equipped to recognize the hidden weight of boredom and how you can help redirect it toward healthy, enriching activities. Encourage coping strategies learned in therapy, build a supportive environment, and celebrate small victories with your teen.
These steps can make all the difference in guiding them to long-term recovery.
To continue this vital conversation, I invite you to follow me on my blog at wesleysassaman.com. There, you'll find engaging, evidence-based content on topics like this—practical tools to help you protect your teen or young adult from the devastating grip of fentanyl and other substances. Together, we can tackle these challenges and help our kids build a brighter, healthier future.
References
Bastien, G., McAnulty, C., Ledjiar, O., Socías, M. E., Le Foll, B., Lim, R., Hassan, A. N., Brissette, S., Marsan, S., Talbot, A., & Jutras-Aswad, D. (2022). Effects of buprenorphine/naloxone and methadone on depressive symptoms in people with prescription opioid use disorder: A pragmatic randomised controlled trial. The Canadian Journal of Psychiatry.
Baudewin, C. (2022). Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: Evidence from a dopamine challenge study. Molecular Psychiatry, 27(10), 4113–4121.
Blanco-Pozo, M., Akam, T., & Walton, M. E. (2024). Dopamine-independent effect of rewards on choices through hidden-state inference. Nature Neuroscience.
Chao, T., Todman, M., Foltin, R. W., Evans, S. M., & Bedi, G. (2023). Laboratory method to induce state boredom increases impulsive choice in people who use cocaine and controls. American Journal of Drug and Alcohol Abuse, 50(1).
Chou, T., & D'Orsogna, M. R. (2022). A mathematical model of reward-mediated learning in drug addiction. Chaos, 32(2), 021102.
Cicolini, A., Orsolini, L., Longo, G., Silvestrini, M., & Volpe, U. (2023). Boredom, emotional dysregulation and avoidance coping strategies: Which is their role in youth mood disorders? European Psychiatry, 66, S716–S717.
Dresp-Langley, B. (2023). From reward to anhedonia: Dopamine function in the global mental health context. Biomedicines.
Guo, C.-L., Luo, Y., Sun, J.-F., Lei, Z., & Fang, J. (2023). Altered neural activity in the reward-related circuit associated with anhedonia in mild to moderate Major Depressive Disorder. Journal of Affective Disorders.
Hamburger, D. (2022). Dopamine errors drive excitatory and inhibitory components of backward conditioning in an outcome-specific manner. Current Biology, 32(14), 3210-3218.e3.
Jeong, H., Taylor, A., Floeder, J., Lohmann, M., Mihalas, S., Wu, B., Zhou, M., Burke, D. A., & Namboodiri, V. M. K. (2022). Mesolimbic dopamine release conveys causal associations. Science, 378(6626).
Jovanoski, K. D., Duquenoy, L., Mitchell, J., Kapoor, I., Treiber, C. D., Croset, V., Dempsey, G., Parepalli, S., Cognigni, P., Otto, N., Felsenberg, J., & Waddell, S. (2023). Dopaminergic systems create reward seeking despite adverse consequences. Nature.
Krishnamurthy, V. B., Yadav, S. R., Vgontzas, A. N., Bixler, E. O., & Fernandez-Mendoza, J. (2023). Insomnia, hypersomnia, and depression in buprenorphine-treated opioid use disorder subjects. Sleep, 46(Supplement_1), A180–A180.
Kuhn, B. N., Campus, P., Klumpner, M. S., Chang, S. E., Iglesias, A. G., & Flagel, S. B. (2021). Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in “relapse prone” male rats. Psychopharmacology, 1–17.
MacNiven, K. H., Mortazavi, L., & Knutson, B. (2023). Blunted neurobehavioral loss anticipation predicts relapse to stimulant drug use. Biological Psychiatry.
Mao, S., Chou, T., & D'Orsogna, M. R. (2024). A probabilistic model of relapse in drug addiction. Mathematical Biosciences, 109184.
Naudé, J., Sarazin, M., Mondoloni, S., Hannesse, B., Vicq, É., Amegandjin, F., Mourot, A., Fauré, P., & Delord, B. (2024). Dopamine builds and reveals reward-associated latent behavioral attractors. Nature Communications, 15(1).
Perone, S., Weybright, E. H., & Anderson, A. J. (2019). Over and over again: Changes in frontal EEG asymmetry across a boring task. Psychophysiology, e13427.
Riblet, N. B. V., Young-Xu, Y., Shiner, B., Schnurr, P. P., & Watts, B. V. (2023). The efficacy and safety of buprenorphine for the treatment of depression: A systematic review and meta-analysis. Journal of Psychiatric Research, 161, 393–401.
Schultz, W. (2024). A dopamine mechanism for reward maximization. Proceedings of the National Academy of Sciences, 121(20), e2316658.
Shadowen, H. M., Violante, S., Gataric, A., Goulding, A. N., & Martin, C. E. (2022). Psychiatric comorbidities and their treatment predict buprenorphine continuation among postpartum people with opioid use disorder. Drug and Alcohol Dependence, 5, 100121.
Shota, F. (2022). The dopamine system in mediating alcohol effects in humans. Current Topics in Behavioral Neuroscience.
Siemsen, B. M., Franco, D., & Lobo, M. K. (2022). Corticostriatal contributions to dysregulated motivated behaviors in stress, depression, and substance use disorders. Neuroscience Research.
Stewart, J. (2008). Psychological and neural mechanisms of relapse. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(15).
Weiss, F., Ciccocioppo, R., Parsons, L. H., Katner, S. N., Liu, X., Zorrilla, E. P., Valdez, G. R., Ben-Shahar, O., Angeletti, S., & Richter, R. R. (2006). Compulsive drug-seeking behavior and relapse: Neuroadaptation, stress, and conditioning factors. Annals of the New York Academy of Sciences, 937.
Xie, Y.-F., Huang, L., Corona, A. M., Pagliaro, A. H., & Shea, S. D. (2022). A dopaminergic reward prediction error signal shapes maternal behavior in mice. Neuron, 111(4), 557-570.e7.
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